Article

Role of KMT2B and KMT2D histone 3, lysine 4 methyltransferases and DNA oxidation status in circulating breast cancer cells provide insights into cell-autonomous regulation of cancer stem cells

2024-01-03

Abstract excerpt

<title>Abstract</title> <p>Background Breast cancer cells (BCCs) can remain undetected for decades in dormancy. These quiescent cells are similar to cancer stem cells (CSCs); hence their ability to initiate tertiary metastasis. Dormancy can be regulated by components of the tissue microenvironment such as bone marrow mesenchymal stem cells (MSCs) releasing exosomes to dedifferentiate BCCs into CSCs. The exosomes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4273ab61-9469-59cb-af75-37257225dc68
DOI: 10.21203/rs.3.rs-3822758/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of KMT2B and KMT2D histone 3, lysine 4 methyltransferases and DNA oxidation status in circulating breast cancer cells provide insights into cell-autonomous regulation of cancer stem cellsDOI 10.21203/rs.3.rs-3822758/v1Read

Decoding the adaptive survival mechanisms of breast cancer dormancySemantic proximity Read

Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy.Semantic proximity Read

Gene expression predicts dormant metastatic breast cancer cell phenotype.Semantic proximity Read

Pan-cancer survey of tumour mass dormancy and underlying mutational processesSemantic proximity Read

Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancerSemantic proximity Read

Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.Semantic proximity Read

Cancer cell dormancy: An update to 2025Semantic proximity Read

Targeting hypoxia-induced circSTT3A decreases breast cancer stem cell formation via degradation of PGK1 protein and serine synthesisSemantic proximity Read

Tumor Cell Dormancy: Threat or Opportunity in the Fight against CancerSemantic proximity Read

Natural killer cell regulation of breast cancer stem cells mediates metastatic dormancySemantic proximity Read

MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancerSemantic proximity Read

Developing a dormancy-associated ECM signature in TNBC that is linked to immunosuppressive tumor microenvironment and selective sensitivity to MAPK inhibitorsSemantic proximity Read