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Article

Mutation of gdpS gene induces a viable but non-culturable state in Staphylococcus epidermidis and changes in the global transcriptional profile.

BMC microbiology - 1 Dec 2022

Zhu Tao, Wang Wei, Wang Han, Zhao Yanfeng, Qu Di, Wu Yang

Abstract excerpt

BACKGROUND: In the genome of staphylococci, only the gdpS gene encodes the conserved GGDEF domain, which is the characteristic of diguanylate cyclases. In our previous study, we have demonstrated that the gdpS gene can modulate biofilm formation by positively regulating the expression of ica operon in Staphylococcus epidermidis. Moreover, this regulation seems to be independent of the c-di-GMP signaling pathway...

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PMID: 36457079
DOI: 10.1186/s12866-022-02708-6
PMCID: PMC9714401

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