Article
Impact of the accessory gene regulatory system (Agr) on extracellular proteins, codY expression and amino acid metabolism in Staphylococcus epidermidis.
Proteomics - 1 Jun 2006
Batzilla Christoph F, Rachid Shwan, Engelmann Susanne, Hecker Michael, Hacker Jörg, Ziebuhr Wilma
Abstract excerpt
The quorum-sensing system Agr is part of a complex regulatory network of gene expression in staphylococci. This study presents the effect of an agr mutation on a biofilm-forming Staphylococcus epidermidis isolate by employing proteome and transcriptome analysis. The agr mutant exhibited a significantly lowered amount of extracellular proteins: amongst others SspA, AtlE, GehD and the phenol soluble modulins...
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