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Article

Varied histomorphology and clinical outcomes of FGFR3-TACC3 fusion gliomas.

Neurosurgical focus - 1 Dec 2022

McDonald Malcolm F, Athukuri Prazwal, Anand Adrish, Gopakumar Sricharan, Jalali Ali, Patel Akash J, Rao Ganesh, Goodman J Clay, Lu Hsiang-Chih, Mandel Jacob J

Abstract excerpt

Targeted therapies for driver gene fusions in cancers have yielded substantial improvements in care. Here, the authors outline a case series of 6 patients with FGFR3-TACC3 fusion in primary brain tumors ranging from polymorphous low-grade neuroepithelial tumor of the young to papillary glioneuronal tumors and glioblastoma (GBM). Previous studies indicated the FGFR3-TACC3 fusion provides survival benefit to GBM...

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PMID: 36455273
DOI: 10.3171/2022.9.FOCUS22420

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