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Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions

9 Nov 2020

Abstract excerpt

A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impact on survival in 906 IDH-wildtype GBM patients. We establish an F3T3 prevalence of 4.1% and delineate its...

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PMID: 33168106
DOI: 10.1186/s40478-020-01058-6

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