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Article

Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

22 Jan 2015

Abstract excerpt

PURPOSE: Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have been proposed as new therapeutic targets. We analyzed frequency and molecular features of FGFR-TACC fusions and explored the therapeutic efficacy of inhibiting FGFR kinase in GBM and grade II and III glioma. EXPERIMENTAL DESIGN: Overall, 795...

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PMID: 25609060
DOI: 10.1158/1078-0432.ccr-14-2199

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