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Article

Diffuse glioma with FGFR3-TACC3 fusion in adults is not a homogenous clinicopathological and molecular entity.

The journal of pathology. Clinical research - 1 Nov 2025

Su Xiaoli, Wu Jiawen, Wang Pingling, Hu Liwen, Chen Yupeng, Ren Caihong, Song Fangling, Lin Hangrui, Ji Chenlin, Xie Yucheng, Wang Xingfu

Abstract excerpt

Adult diffuse gliomas with FGFR3-TACC3 (F3T3) fusion are rare and highly heterogeneous central nervous system (CNS) tumors. Current research on the biological behavior of these tumors is limited, especially regarding whether histopathologically low-grade tumors are indolent or represent early-stage high-grade tumors, thereby posing challenges for grading. In this single-center study of 17 patients with adult F3T3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41165398
DOI: 10.1002/2056-4538.70057
PMCID: PMC12573470

Genes

FGFR3
TACC3
TERT
CDK4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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