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Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinum

30 Nov 2022

Abstract excerpt

Pathogenic mycobacteria are bacteria that pose a large burden to human health globally. The ESX-1 secretion system is required for pathogenic mycobacteria to survive within and interact with the host. Proper function of the ESX-1 secretion system is achieved by tightly controlling the expression of secreted virulence factors, in part through transcriptional regulation. Here, we characterize the conserved...

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PMID: 36448785
DOI: 10.1128/jb.00233-22

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Research trail→

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Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinumPMID 36448785Read ↗

EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 SystemSemantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in <i>M. marinum</i>Semantic proximity Read ↗

Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene ExpressionSemantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinumSemantic proximity Read ↗

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in <i>M. marinum</i>Semantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspFSemantic proximity Read ↗

A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium–Host InteractionSemantic proximity Read ↗

WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinumSemantic proximity Read ↗

The Enigmatic Esx Proteins: Looking Beyond MycobacteriaSemantic proximity Read ↗

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