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A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium–Host Interaction

30 Jun 2021

Abstract excerpt

As a major effector of the ESX-1 secretion system, EsxA is essential for the virulence of pathogenic mycobacteria, such as Mycobacterium tuberculosis (Mtb) and Mycobacterium marinum (Mm). EsxA possesses an acidic pH-dependent membrane permeabilizing activity and plays an essential role by mediating mycobacterial escape from the phagosome and translocation to the cytosol for intracellular replication. Moreover,...

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PMID: 34209120
DOI: 10.3390/cells10071645

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