Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Abstract excerpt

Autophagy is essential for neuronal development and its deregulation contributes to neurodegenerative diseases. NDR1 and NDR2 are highly conserved kinases, implicated in neuronal development, mitochondrial health and autophagy, but how they affect mammalian brain development in vivo is not known. Using single and doubleNdr1/2knockout mouse models, we show that only dual loss ofNdr1/2in neurons causes...