Article

Identification of Most Lethal Non-synonymous SNPs in Tollip gene- An In-Silico Analysis

2021-09-23

Abstract excerpt

The Toll-interacting protein (TOLLIP), first detected by hybrid screening using Interleukin-1 receptor accessory protein in 2000, is ubiquitous and its TLR signaling cascade gets negatively regulated by TOLLIP in particular by impeding the TLR4 and TLR2 pathways. Toll-interacting protein facilitates TLR and TGF-β type 1 receptor intracellular localization and lysosomal degradation and exerts its anti-apoptosis and...

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Literature Corpus work: ed5a5bfd-aa72-56e4-9589-ab3ef8a79fb1
DOI: 10.21203/rs.3.rs-488110/v4

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