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Article

Computational analysis of structural and functional evaluation of the deleterious missense variants in the human CTLA4 gene.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Bouqdayr Meryem, Abbad Anass, Baba Hanâ, Saih Asmae, Wakrim Lahcen, Kettani Anass

Abstract excerpt

CTLA-4 is an immune checkpoint receptor that negatively regulates the T-cell function expressed after T-cell activation to break the immune response. The current study predicted the genomic analysis to explore the functional variations of missense SNPs in the human CTLA4 gene using PolyPhen2, SIFT, PANTHER, PROVEAN, Fathmm, Mutation Assessor, PhD-SNP, SNPs&GO, SNAP2, and MutPred2. Phylogenetic conservation...

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Computational Biology
CTLA-4 Antigen
Molecular Dynamics Simulation
Mutation
Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 36764830
DOI: 10.1080/07391102.2023.2178509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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