Article
PLCG1 mutations in cutaneous T-cell lymphomas.
Blood - 27 Mar 2014
Vaqué José P, Gómez-López Gonzalo, Monsálvez Verónica, Varela Ignacio, Martínez Nerea, Pérez Cristina, Domínguez Orlando, Graña Osvaldo, Rodríguez-Peralto José L, Rodríguez-Pinilla Socorro M, González-Vela Carmen, Rubio-Camarillo Miriam, Martín-Sánchez Esperanza, Pisano David G, Papadavid Evangelia, Papadaki Theodora, Requena Luis, García-Marco José A, Méndez Miriam, Provencio Mariano, Hospital Mercedes, Suárez-Massa Dolores, Postigo Concepción, San Segundo David, López-Hoyos Marcos, Ortiz-Romero Pablo L, Piris Miguel A, Sánchez-Beato Margarita
Abstract excerpt
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of primary cutaneous T-cell lymphoproliferative processes, mainly composed of mycosis fungoides and Sézary syndrome, the aggressive forms of which lack an effective treatment. The molecular pathogenesis of CTCL is largely unknown, although neoplastic cells show increased signaling from T-cell receptors (TCRs). DNAs from 11 patients with CTCL, both normal...
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