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Article

The effects of naturally occurring mutations on functionality of oxylipin metabolizing dehydrogenase reductase nine.

The Journal of biological chemistry - 1 Oct 2025

Wirth Samuel E, Pakhomova Svetlana, Belyaeva Olga V, Boeglin William E, Brash Alan R, Newcomer Marcia E, Kedishvili Natalia Y, Popov Kirill M

Abstract excerpt

Recent evidence suggests that dehydrogenase reductase 9 (DHRS9) can oxidize and alter the biological activity of a diverse group of oxylipin substrates, underscoring the importance of DHRS9 in regulating various biological processes, including inflammation, cell proliferation, and tissue repair. Importantly, mutations in the DHRS9 gene resulting in amino acid substitutions S202L and D286H have been linked to an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40945732
DOI: 10.1016/j.jbc.2025.110704
PMCID: PMC12538056

Genes

DHRS9

Variants

Provenance

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