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Spatial multiomics map of trophoblast development in early pregnancy

29 Mar 2023

Abstract excerpt

Abstract The relationship between the human placenta—the extraembryonic organ made by the fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-conductance vessels1. Defects in trophoblast invasion and arterial...

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PMID: 36991123
DOI: 10.1038/s41586-023-05869-0

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