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Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

1 Jan 2022

Abstract excerpt

In early placental development, progenitor cytotrophoblasts (CTB) differentiate along one of two cellular trajectories: the villous or extravillous pathways. CTB committed to the villous pathway fuse with neighboring CTB to form the outer multinucleated syncytiotrophoblast (SCT), whereas CTB committed to the extravillous pathway differentiate into invasive extravillous trophoblasts (EVT). Unfortunately, little is...

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PMID: 35020896
DOI: 10.1242/dev.199840

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