Article
High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls.
PloS one - 1 Jan 2022
Valori Miko, Lehikoinen Joonas, Jansson Lilja, Clancy Jonna, Lundgren Sofie A, Mustjoki Satu, Tienari Pentti
Abstract excerpt
Somatic mutations have a central role in cancer, but there are also a few rare autoimmune diseases in which somatic mutations play a major role. We have recently shown that nonsynonymous somatic mutations with low allele fractions are preferentially detectable in CD8+ cells and that the STAT3 gene is a promising target for screening. Here, we analyzed somatic mutations in the STAT3 SH2 domain in peripheral blood...
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