Article
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia.
Leukemia - 1 May 2021
Lundgren Sofie, Keränen Mikko A I, Kankainen Matti, Huuhtanen Jani, Walldin Gunilla, Kerr Cassandra M, Clemente Michael, Ebeling Freja, Rajala Hanna, Brück Oscar, Lähdesmäki Harri, Hannula Sari, Hannunen Tiina, Ellonen Pekka, Young Neal S, Ogawa Seishi, Maciejewski Jaroslaw P, Hellström-Lindberg Eva, Mustjoki Satu
Abstract excerpt
The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In immune-mediated aplastic anemia (AA), cytotoxic T-cell expansions are shown to participate in disease pathogenesis. We investigated the mutation profiles of T cells in AA by a custom panel of 2533 genes. We sequenced CD4+ and CD8+ T cells of 24 AA patients...
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