Somatic STAT3 mutations in large granular lymphocytic leukemia.

doi:10.1056/NEJMoa1114885

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Article

Somatic STAT3 mutations in large granular lymphocytic leukemia.

The New England journal of medicine - 17 May 2012

Koskela Hanna L M, Eldfors Samuli, Ellonen Pekka, van Adrichem Arjan J, Kuusanmäki Heikki, Andersson Emma I, Lagström Sonja, Clemente Michael J, Olson Thomas, Jalkanen Sari E, Majumder Muntasir Mamun, Almusa Henrikki, Edgren Henrik, Lepistö Maija, Mattila Pirkko, Guinta Kathryn, Koistinen Pirjo, Kuittinen Taru, Penttinen Kati, Parsons Alun, Knowles Jonathan, Saarela Janna, Wennerberg Krister, Kallioniemi Olli, Porkka Kimmo, Loughran Thomas P, Heckman Caroline A, Maciejewski Jaroslaw P, Mustjoki Satu

Abstract excerpt

BACKGROUND: T-cell large granular lymphocytic leukemia is a rare lymphoproliferative disorder characterized by the expansion of clonal CD3+CD8+ cytotoxic T lymphocytes (CTLs) and often associated with autoimmune disorders and immune-mediated cytopenias. METHODS: We used next-generation exome sequencing to identify somatic mutations in CTLs from an index patient with large granular lymphocytic leukemia. Targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Large Granular Lymphocytic

Share to Receptors, Antigen, T-Cell

Share to Sequence Analysis, RNA

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Identifiers

PMID: 22591296
DOI: 10.1056/NEJMoa1114885
PMCID: PMC3693860

Genes

STAT3
IFNGR2
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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