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Article

CD8+ cell somatic mutations in multiple sclerosis patients and controls-Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies.

PloS one - 1 Jan 2021

Valori Miko, Jansson Lilja, Tienari Pentti J

Abstract excerpt

Somatic mutations have a central role in cancer but their role in other diseases such as common autoimmune disorders is not clear. Previously we and others have demonstrated that especially CD8+ T cells in blood can harbor persistent somatic mutations in some patients with multiple sclerosis (MS) and rheumatoid arthritis. Here we concentrated on CD8+ cells in more detail and tested (i) how commonly somatic...

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Identifiers

PMID: 34874980
DOI: 10.1371/journal.pone.0261002
PMCID: PMC8651110

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