Article
A novel class of somatic mutations in blood detected preferentially in CD8+ cells.
Clinical immunology (Orlando, Fla.) - 1 Feb 2017
Valori Miko, Jansson Lilja, Kiviharju Anna, Ellonen Pekka, Rajala Hanna, Awad Shady Adnan, Mustjoki Satu, Tienari Pentti J
Abstract excerpt
Somatic mutations have a central role in cancer but their role in other diseases such as autoimmune disorders is poorly understood. Earlier work has provided indirect evidence of rare somatic mutations in autoreactive T-lymphocytes in multiple sclerosis (MS) patients but such mutations have not been identified thus far. We analysed somatic mutations in blood in 16 patients with relapsing MS and 4 with other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.