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Article

Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling.

Cancer science - 1 Apr 2023

Yogo Akitada, Masui Toshihiko, Takaishi Shigeo, Masuo Kenji, Chen Ru, Kasai Yosuke, Nagai Kazuyuki, Anazawa Takayuki, Watanabe Sadanori, Sakamoto Satoko, Watanabe Akira, Inagaki Ryosaku, Nakagawa Masahiro M, Ogawa Seishi, Seno Hiroshi, Uemoto Shinji, Hatano Etsuro

Abstract excerpt

Bile duct cancer (BDC) frequently invades the nerve fibers, making complete surgical resection difficult. A single tumor mass contains cells of variable malignancy and cell-differentiation states, with cancer stem cells (CSCs) considered responsible for poor clinical outcomes. This study aimed to investigate the contribution of autosynthesized dopamine to CSC-related properties in BDC. Sphere formation assays...

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Identifiers

PMID: 36441110
DOI: 10.1111/cas.15676
PMCID: PMC10067401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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