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Article

DRD4 promotes chemo-resistance and cancer stem cell-like phenotypes by mediating the activation of the Akt/β-catenin signaling axis in liver cancer.

British journal of cancer - 1 Oct 2024

Yang Zhengyan, Zhang Pai, Zhao Yiwei, Guo Ran, Hu Jinglin, Wang Qi, Zhao Zhi, Liu Handi, Lv Shuangyu, Ren Zhiguang, Hu Yanzhong, Cui Daxiang

Abstract excerpt

BACKGROUND: Liver cancer stem cells (LCSCs) significantly impact chemo-resistance and recurrence in liver cancer. Dopamine receptor D4 (DRD4) is known to enhance the cancer stem cell (CSC) phenotype in glioblastoma and correlates with poor prognosis in some non-central nervous system tumors; however, its influence on LCSCs remains uncertain. METHODS: To investigate the gene and protein expression profiles of DRD4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39174739
DOI: 10.1038/s41416-024-02811-7
PMCID: PMC11442912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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