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Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture method

20 May 2022

Abstract excerpt

Dog bladder cancer (BC) is mostly muscle-invasive (MI) with poor prognosis, and its pathogenesis is close to human MIBC. Three-dimensional (3D) organoid culture ensures novel knowledge on cancer diseases including BC. Recently, we have established dog BC organoids (BCO) using their urine samples. BCO recapitulated the epithelial structures, characteristics, and drug sensitivity of BC-diseased dogs. However,...

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PMID: 35605292
DOI: 10.1016/j.biopha.2022.113105

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