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Article

Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling.

Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2024

Labelle-Dumais Cassandre, Mazur Courtney, Kaya Serra, Obata Yoshihiro, Lee Bryson, Acevedo Claire, Alliston Tamara, Gould Douglas B

Abstract excerpt

Skeletal defects are hallmark features of many extracellular matrix (ECM) and collagen-related disorders. However, a biological function in bone has never been defined for the highly evolutionarily conserved type IV collagen. Collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2) form α1α1α2 (IV) heterotrimers that represent a fundamental basement membrane constituent present in every organ of the body, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39097038
DOI: 10.1016/j.matbio.2024.07.005
PMCID: PMC12032920

Genes

COL4A1
COL4A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling.PMID 39097038Read ↗

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