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Article

Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes.

Acta neuropathologica communications - 12 Aug 2025

Kawatani Keiji, Aikawa Tomonori, Tabrizi Zeynab, Pan Yining, Ren Yingxue, Wang Ni, Kurti Aishe, Nambara Toshihiko, Ikezu Clark C, Shue Francis, Bamkole Michael, Inoue Yasuteru, Parsons Tammee M, Bu Guojun, Song Qianqian, Bracko Oliver, Kanekiyo Takahisa

Abstract excerpt

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and dementia (VCID) and highly associated with Alzheimer's disease pathogenesis. There is an urgent need to establish relevant animal models for cSVD. As aging is the strongest risk factor for these diseases, cerebrovascular senescence is implicated in cSVD pathogenesis. We investigated how AAV-based expression of...

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Source

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Identifiers

PMID: 40796891
DOI: 10.1186/s40478-025-02085-x
PMCID: PMC12345092

Genes

CDKN2A
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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