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Article

Deregulated TGF-β/BMP Signaling in Vascular Malformations.

Circulation research - 29 Sept 2017

Cunha Sara I, Magnusson Peetra U, Dejana Elisabetta, Lampugnani Maria Grazia

Abstract excerpt

Correct organization of the vascular tree requires the balanced activities of several signaling pathways that regulate tubulogenesis and vascular branching, elongation, and pruning. When this balance is lost, the vessels can be malformed and fragile, and they can lose arteriovenous differentiation. In this review, we concentrate on the transforming growth factor (TGF)-β/bone morphogenetic protein (BMP) pathway,...

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Identifiers

PMID: 28963191
DOI: 10.1161/CIRCRESAHA.117.309930

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