Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D HBeAg-positive chronic hepatitis B.

doi:10.1111/apt.17299

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Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D HBeAg-positive chronic hepatitis B.

Alimentary pharmacology & therapeutics - 1 Mar 2023

Wagner Josef, Yuen Lilly, Littlejohn Margaret, Sozzi Vitina, Jackson Kathy, Martin Ross, Aeschbacher Thomas, Suri Vithika, Tan Susanna K, Feierbach Becket, Gaggar Anuj, Marcellin Patrick, Buti Ferret Maria, Janssen Harry L A, Gane Ed, Meagher Niamh, Price David J, Wong Darren, Thompson Alexander T, Revill Peter A

Abstract excerpt

BACKGROUNDS AND AIMS: We investigated associations between hepatitis B virus (HBV) genome-length haplotype number (HN) at baseline in subjects with HBeAg-positive chronic hepatitis B (CHB), and the likelihood of achieving functional cure during direct-acting antiviral therapy METHOD: We analysed 86 HBeAg-positive baseline samples from patients with HBV genotypes A and D who were enrolled in a Phase II trial of...

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PMID: 36427857
DOI: 10.1111/apt.17299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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