Article
No detectable resistance to tenofovir disoproxil fumarate in HBeAg+ and HBeAg- patients with chronic hepatitis B after 8 years of treatment.
Journal of viral hepatitis - 1 Jan 2017
Liu Y, Corsa A C, Buti M, Cathcart A L, Flaherty J F, Miller M D, Kitrinos K M, Marcellin P, Gane E J
Abstract excerpt
A major hurdle in the long-term treatment of chronic hepatitis B (CHB) patients is to maintain viral suppression in the absence of drug resistance. To date, no evidence of resistance to tenofovir disoproxil fumarate (TDF) has been observed. A cumulative evaluation of CHB patients who qualified for resistance surveillance over 8 years of TDF treatment was conducted. Patients in studies GS-US-174-0102 (HBeAg-) and...
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