Article
Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells.
eLife - 3 Jun 2021
Mouat Isobel C, Morse Zachary J, Shanina Iryna, Brown Kelly L, Horwitz Marc S
Abstract excerpt
Epstein-Barr virus (EBV) infection is associated with rheumatoid arthritis (RA) in adults, though the nature of the relationship remains unknown. Herein, we have examined the contribution of viral infection to the severity of arthritis in mice. We have provided the first evidence that latent gammaherpesvirus infection enhances clinical arthritis, modeling EBV's role in RA. Mice latently infected with a murine...
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