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Article

MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

25 Nov 2022

Abstract excerpt

The telomeric repeat-binding factor 2 (TRF2) is a telomere-capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types, and it contributes to cancer progression. To date, anti-cancer strategies to target TRF2 remain a challenge. Here, we developed a miRNA-based approach to reduce TRF2 expression. By performing a high-throughput...

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Share to Advanced biosensing and bioanalysis techniques
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

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PMID: 36426578
DOI: 10.15252/emmm.202216033

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