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Article

miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1

30 May 2014

Abstract excerpt

Telomeres consist of DNA tandem repeats that recruit the multiprotein complex shelterin to build a chromatin structure that protects chromosome ends. Although cancer formation is linked to alterations in telomere homeostasis, there is little understanding of how shelterin function is limited in cancer cells. Using a small-scale screening approach, we identified miR-155 as a key regulator in breast cancer cell...

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Share to Genetics, Aging, and Longevity in Model Organisms
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Share to Telomeres, Telomerase, and Senescence

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PMID: 24876105
DOI: 10.1158/0008-5472.can-13-2038

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