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Cancer Fighting SiRNA-RRM2 Loaded Nanorobots

28 Jan 2020

Abstract excerpt

BACKGROUND: Silencing of several genes is critical for cancer therapy. These genes may be apoptotic gene, cell proliferation gene, DNA synthesis gene, etc. The two subunits of Ribonucleotide Reductase (RR), RRM1 and RRM2, are critical for DNA synthesis. Hence, targeting the blockage of DNA synthesis at tumor site can be a smart mode of cancer therapy. Specific targeting of blockage of RRM2 is done effectively by...

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PMID: 32003677
DOI: 10.2174/2211738508666200128120142

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