Article
Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder.
Journal of integrative neuroscience - 28 Oct 2022
Spitta Gianna, Fliedner Lena E, Gleich Tobias, Zindler Tristan, Sebold Miriam, Buchert Ralph, Heinz Andreas, Gallinat Jürgen, Friedel Eva
Abstract excerpt
BACKGROUND: The association between blunted dopaminergic neurotransmission and alcohol use disorder (AUD) is well-known. In particular, the impairment of postsynaptic dopamine 2 and 3 receptors (DRD2/3) in the ventral and dorsal striatum during the development and maintenance of alcohol addiction has been investigated in several positron emission tomography (PET) studies. However, it is unclear whether these...
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