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Article

Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).

Alcoholism, clinical and experimental research - 1 Feb 2011

Hack Laura M, Kalsi Gursharan, Aliev Fazil, Kuo Po-Hsiu, Prescott Carol A, Patterson Diana G, Walsh Dermot, Dick Danielle M, Riley Brien P, Kendler Kenneth S

Abstract excerpt

BACKGROUND: Over 50 years of evidence from research has established that the central dopaminergic reward pathway is likely involved in alcohol dependence (AD). Additional evidence supports a role for dopamine (DA) in other disinhibitory psychopathology, which is often comorbid with AD. Family and...

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Source

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Identifiers

PMID: 21083670
DOI: 10.1111/j.1530-0277.2010.01353.x
PMCID: PMC3443636

Genes

COMT
DDC
DRD1
DRD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21083670-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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