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Article

SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans.

Genes - 18 Nov 2022

Chaar Dima L, Nguyen Kim, Wang Yi-Zhe, Ratliff Scott M, Mosley Thomas H, Kardia Sharon L R, Smith Jennifer A, Zhao Wei

Abstract excerpt

SNPs in ABCA7 confer the largest genetic risk for Alzheimer's Disease (AD) in African Americans (AA) after APOE ε4. However, the relationship between ABCA7 and cognitive function has not been thoroughly examined. We investigated the effects of five known AD risk SNPs and 72 CpGs in ABCA7, as well as their interactions, on general cognitive function (cognition) in 634 older AA without dementia from Genetic...

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Identifiers

PMID: 36421824
DOI: 10.3390/genes13112150
PMCID: PMC9691156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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