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Article

Association of Polygenic Risk Score With Lifetime Risk of Developing Multiple Sclerosis in a Population-Based Birth-Year Cohort.

Neurology - 8 Oct 2024

Loonstra Floor C, Álvarez Sirvent Daniel, Tesi Niccoló, Holstege Henne, Strijbis Eva M M, Salazar Alex N, Hulsman Marc, Van Der Lee Sven J, Uitdehaag Bernard

Abstract excerpt

BACKGROUND AND OBJECTIVES: More than 200 genetic variants have been associated with multiple sclerosis (MS) susceptibility. However, it is unclear to what extent genetic factors influence lifetime risk of MS. Using a population-based birth-year cohort, we investigate the effect of genetics on lifetime risk of MS. METHODS: In the Project Y study, we tracked down almost all persons with MS (pwMS) from birth year...

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Identifiers

PMID: 39270152
DOI: 10.1212/WNL.0000000000209663
PMCID: PMC11399064

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