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Lack of evolutionary convergence in multiple primary lung cancer suggests insufficient specificity of personalized therapy.

Journal of genetics and genomics = Yi chuan xue bao - 1 May 2023

Cheng Hua, Guo Ziyan, Zhang Xiaoyu, Wang Xiao-Jin, Li Zizhang, Huo Wen-Wen, Zhong Hong-Cheng, Li Xiao-Jian, Wu Xiang-Wen, Li Wen-Hao, Chen Zhuo-Wen, Wu Tian-Chi, Gan Xiang-Feng, Zhong Bei-Long, Lyubetsky Vassily A, Rusin Leonid Yu, Yang Junnan, Zhao Qiyi, Cao Qing-Dong, Yang Jian-Rong

Abstract excerpt

Multiple primary lung cancer (MPLC) is an increasingly prevalent subtype of lung cancer. According to recent genomic studies, the different lesions of a single MPLC patient exhibit functional similarities that may reflect evolutionary convergence. We perform whole-exome sequencing for a unique cohort of MPLC patients with multiple samples from each lesion found. Using our own and other relevant public data,...

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Identifiers

PMID: 36414223
DOI: 10.1016/j.jgg.2022.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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