Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML).

doi:10.1038/s41375-022-01751-6

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Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML).

Leukemia - 1 Jan 2023

Steinhäuser Sophie, Silva Patricia, Lenk Lennart, Beder Thomas, Hartmann Alina, Hänzelmann Sonja, Fransecky Lars, Neumann Martin, Bastian Lorenz, Lipinski Simone, Richter Kathrin, Bultmann Miriam, Hübner Emely, Xia Shuli, Röllig Christoph, Vogiatzi Fotini, Schewe Denis Martin, Yumiceba Veronica, Schultz Kristin, Spielmann Malte, Baldus Claudia Dorothea

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by complex molecular alterations and driver mutations. Elderly patients show increased frequencies of IDH mutations with high chemoresistance and relapse rates despite recent therapeutic advances. Besides being associated with global promoter hypermethylation, IDH1 mutation facilitated changes in 3D DNA-conformation by CTCF-anchor methylation and upregulated oncogene...

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PMID: 36411356
DOI: 10.1038/s41375-022-01751-6
PMCID: PMC9883162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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