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Article

EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients.

Journal of molecular cell biology - 1 Dec 2017

Zhang Le, Liu Ying, Wang Mengning, Wu Zhenhai, Li Na, Zhang Jinsong, Yang Chuanwei

Abstract excerpt

Glioma is a complex disease with limited treatment options. Recent advances have identified isocitrate dehydrogenase (IDH) mutations in up to 80% lower grade gliomas (LGG) and in 76% secondary glioblastomas (GBM). IDH mutations are also seen in 10%-20% of acute myeloid leukemia (AML). In AML, it was determined that mutations of IDH and other genes involving epigenetic regulations are early events, emerging in the...

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Source

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Identifiers

PMID: 29272522
DOI: 10.1093/jmcb/mjx056
PMCID: PMC5907834

Genes

CHD4
IDH1
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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