Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.

Nature cell biology - 21 Aug 2011

Richter Constance, Oktaba Katarzyna, Steinmann Jonas, Müller Jürg, Knoblich Juergen A

Abstract excerpt

In Drosophila, defects in asymmetric cell division often result in the formation of stem-cell-derived tumours. Here, we show that very similar terminal brain tumour phenotypes arise through a fundamentally different mechanism. We demonstrate that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Cycle Proteins
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Microscopy, Fluorescence

Share to Optic Lobe, Nonmammalian

Share to Protein Kinases

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21857667
DOI: 10.1038/ncb2306
PMCID: PMC3173870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.PMID 21857667Read ↗

LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.Semantic proximity Read ↗

Lint‐O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brainSemantic proximity Read ↗

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscapeSemantic proximity Read ↗

Human <i>Brat</i> Ortholog <i>TRIM3</i> Is a Tumor Suppressor That Regulates Asymmetric Cell Division in GlioblastomaSemantic proximity Read ↗

KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasisSemantic proximity Read ↗

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.Semantic proximity Read ↗

Illuminati: a form of gene expression plasticity in Drosophila neural stem cells.Semantic proximity Read ↗

A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.Semantic proximity Read ↗

Meis1 coordinates a network of genes implicated in eye development and microphthalmiaSemantic proximity Read ↗

The H3.3K27M oncohistone antagonizes reprogramming in Drosophila.Semantic proximity Read ↗

Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system.Semantic proximity Read ↗

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.