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Article

Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2023

Huang Jinghan, Stein Thor D, Wang Yixuan, Ang Ting Fang Alvin, Tao Qiushan, Lunetta Kathryn L, Massaro Joseph, Akhter-Khan Samia C, Mez Jesse, Au Rhoda, Farrer Lindsay A, Zhang Xiaoling, Qiu Wei Qiao

Abstract excerpt

INTRODUCTION: C-Reactive protein (CRP) and monocyte chemoattractant protein-1 (MCP-1) are both implicated in the peripheral proinflammatory cascade and blood-brain barrier (BBB) disruption. Since the blood CRP level increases Alzheimer's disease (AD) risk depending on the apolipoprotein E (APOE) genotype, we hypothesized that the blood MCP-1 level exerts different effects on the AD risk depending on the...

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Identifiers

PMID: 36396603
DOI: 10.1002/alz.12851
PMCID: PMC10182187

Genes

APOE
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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