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Article

Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer's Disease and Mild Cognitive Impairment: A Two-year Follow-up Study.

Scientific reports - 19 Jan 2018

Lee Wei-Ju, Liao Yi-Chu, Wang Yen-Feng, Lin I-Feng, Wang Shuu-Jiun, Fuh Jong-Ling

Abstract excerpt

Monocyte chemoattractant protein-1 (MCP-1, also known as chemokine CCL2) is a vital chemokine that mediates inflammation in Alzheimer's disease (AD). We analyzed the associations between the baseline plasma MCP-1 level, longitudinal cognitive changes, and genetic effects of CCL2 rs1024611 and its receptor, CC-chemokine receptor 2 (CCR2) rs1799864, in AD. In total, 310 AD patients and 66 mild cognitive impairment...

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Identifiers

PMID: 29352259
DOI: 10.1038/s41598-018-19807-y
PMCID: PMC5775300

Genes

CCR2
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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