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Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE ɛ4 Carriers

15 Jul 2021

Abstract excerpt

Background and Objectives Previous research has shown that elevated blood C-reactive protein (CRP) is associated with increased Alzheimer disease (AD) risk only in APOE ε4 allele carriers; the objective of this study was to examine the interactive effects of plasma CRP and APOE genotype on cognition and AD biomarkers. Methods Data from the Alzheimer9s Disease Neuroimaging Initiative (ADNI) study were analyzed,...

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PMID: 34266923
DOI: 10.1212/wnl.0000000000012512

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