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Article

Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer's disease.

Neurobiology of disease - 1 Feb 2026

Huang Jinghan, Rehman Habbiburr, Doan Chinh, Stein Thor D, Mez Jesse, Ang Ting Fang Alvin, Tao Qiushan, Au Rhoda, Farrer Lindsay A, Zhang Xiaoling, Qiu Wei Qiao

Abstract excerpt

BACKGROUND: C-reactive protein (CRP) is a key marker of systemic inflammation that affects blood vessel endothelial function, including in the brain. Since endothelial dysfunction is linked to Alzheimer's disease (AD), we investigated whether elevated CRP level interacts with genetic pathways in brain endothelial cells to influence AD risk. METHODS: Using AD genome-wide association study (GWAS) data, we developed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41539445
DOI: 10.1016/j.nbd.2026.107257
PMCID: PMC12919661

Genes

CRP
APOE
APP
FN1
IL6ST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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