Article

Immune system and blood-brain barrier-wide biomarker analyses provide causal evidence for autoimmunity in dementia

2022-02-18

Abstract excerpt

Immune system and blood brain barrier (BBB) dysfunction are implicated in the development of Alzheimer’s disease and other dementias, but their causal role remains unknown. We performed Mendelian randomization (MR) for over 43,643 immune system and BBB-related biomarkers and identified 126 potential causal risk factors for dementias. A phenome-wide analysis using MR-based polygenic risk score in FinnGen study (N=3...

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Literature Corpus work: e0acca39-bf8d-597b-9c9d-0700b2d967c4
DOI: 10.1101/2022.02.17.22271136

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