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Article

FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation.

Blood - 23 Mar 2023

Li Yanan, Yang Wei, Patel Riddhi M, Casey Emily B, Denby Elisabeth, Mendoza-Castrejon Jonny, Rodriguez-Lopez Priscilla, Magee Jeffrey A

Abstract excerpt

Acute myeloid leukemia (AML) initiation requires multiple rate-limiting mutations to cooperatively reprogram progenitor cell identity. For example, FLT3 internal tandem duplication (FLT3ITD) mutations cooperate with a variety of different initiating mutations to reprogram myeloid progenitor fate. These initiating mutations often skew toward either pediatric or adult AML patient populations, though FLT3ITD itself...

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Identifiers

PMID: 36395068
DOI: 10.1182/blood.2022016889
PMCID: PMC10082380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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