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Article

Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia.

Journal of medical genetics - 1 Feb 2018

Wen Wei Xiong, Allen Jamie, Lai Kah Nyin, Mariapun Shivaani, Hasan Siti Norhidayu, Ng Pei Sze, Lee Daphne Shin-Chi, Lee Sheau Yee, Yoon Sook-Yee, Lim Joanna, Lau Shao Yan, Decker Brennan, Pooley Karen, Dorling Leila, Luccarini Craig, Baynes Caroline, Conroy Don M, Harrington Patricia, Simard Jacques, Yip Cheng Har, Mohd Taib Nur Aishah, Ho Weang Kee, Antoniou Antonis C, Dunning Alison M, Easton Douglas F, Teo Soo Hwang

Abstract excerpt

BACKGROUND: Genetic testing for BRCA1 and BRCA2 is offered typically to selected women based on age of onset and family history of cancer. However, current internationally accepted genetic testing referral guidelines are built mostly on data from cancer genetics clinics in women of European descent. To evaluate the appropriateness of such guidelines in Asians, we have determined the prevalence of germ line...

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BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

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Identifiers

PMID: 28993434
DOI: 10.1136/jmedgenet-2017-104947
PMCID: PMC5800345

Genes

BRCA1
BRCA2

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