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Article

Human BRCA pathogenic variants were originated during recent human history.

Life science alliance - 1 May 2022

Li Jiaheng, Zhao Bojin, Huang Teng, Qin Zixin, Wang San Ming

Abstract excerpt

BRCA1 and BRCA2 (BRCA) play essential roles in maintaining genome stability. BRCA germline pathogenic variants increase cancer risk. However, the evolutionary origin of human BRCA pathogenic variants remains largely elusive. We tested the 2,972 human BRCA1 and 3,652 human BRCA2 pathogenic variants from ClinVar database in 100 vertebrates across eight clades, but failed to find evidence to show cross-species...

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Identifiers

PMID: 35165121
DOI: 10.26508/lsa.202101263
PMCID: PMC8860097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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