Article

Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn’s disease, suggest that a bacterial invasive challenge, rather than global dysbiosis, is the initiating factor

2024-09-28

Abstract excerpt

Crohn’s disease is a chronic, transmural inflammatory disease of the human gut. Changes in the faecal microbial composition and a reduction in species diversity (dysbiosis) are consistent features in studies of Crohn’s disease patients, but whether dysbiosis is a cause or consequence of inflammation remains unresolved. Genetic susceptibility also plays a role in the development of Crohn’s disease and has been link...

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Literature Corpus work: a14a67eb-313d-5f49-85b0-c44e113ec4e1
DOI: 10.1101/2024.09.28.615566

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Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn’s disease, suggest that a bacterial invasive challenge, rather than global dysbiosis, is the initiating factorDOI 10.1101/2024.09.28.615566Read

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